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Verruculogen

Tremorgenic mycotoxin. Potent inhibitors of Ca activated K(maxi K) channel (from):. . A neurotoxin that blocks Ca2+-activated K+ channels. Also arrests cell cycle in M phase Molecular formula C27H33N3O7 Molecular weight 511.6 Gallagher, R. T.; Latch, G. C. M. (1977) Production of the tremorgenic mycotoxins verruculogen and fumitremorgin B by Penicillium piscarium Westling. Appl Environ Microbiol 33(3):730-731 (fromn:) Verruculogen, a potent tremorgen, and fumagillin, formerly used as a cytostatic drug, are mycotoxins found in Aspergillus fumigatus. Penicillium crustosum and Penicillium brevicompactum each produced the tremorgens roquefortine C and penitrem A. The mycotoxin standards library can be used to identify specific mold species in ambient air samples from environmental and occupational investigations. about production of verruculogen (J Gen Microbiol 1980 Apr;117(2):405-10) alternate names: Verruculogen

Tremorgenic mycotoxin. Potent inhibitors of Ca activated K(maxi K) channel

(from):. . A neurotoxin that blocks Ca²⁺-activated K⁺ channels. Also arrests cell cycle in M phase

Molecular formula C₂₇H₃₃N₃O₇ Molecular weight 511.6

Gallagher, R. T.; Latch, G. C. M. (1977) Production of the tremorgenic
mycotoxins verruculogen and fumitremorgin B by Penicillium piscarium
Westling. Appl Environ Microbiol 33(3):730-731

(fromn) Verruculogen, a potent tremorgen, and fumagillin, formerly used as a cytostatic drug, are mycotoxins found in Aspergillus fumigatus. Penicillium crustosum and Penicillium brevicompactum each produced the tremorgens roquefortine C and penitrem A. The mycotoxin standards library can be used to identify specific mold species in ambient air samples from environmental and occupational investigations.

about production of verruculogen (J Gen Microbiol 1980 Apr;117(2):405-10)

Verruculogen associated with Aspergillus fumigatushyphae and conidia modifies the electrophysiological properties of human nasal epithelial cells
BMC Microbiology 2007, 7:5
Khaled Khoufache , Olivier Puel , Nicolas Loiseau , Marcel Delaforge , Daniele Rivollet , Andre Coste , Catherine Cordonnier , Estelle Escudier , Francoise Botterel and Stephane Bretagne
The role of Aspergillus fumigatus mycotoxins in the colonization of the respiratory tract by conidia has not been studied extensively, even though patients at risk from invasive aspergillosis frequently exhibit respiratory epithelium damage. In a previous study, we found that filtrates of A. fumigatus cultures can specifically alter the electrophysiological properties of human nasal epithelial cells (HNEC) compared to those of non pathogenic moulds.

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